Author

Christian L. Egly

University of HoustonORCID 0000-0002-1755-7142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:electronic health records· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Björn C. KnollmanniD· 3 shared Brett M. KronckeiD· 2 shared Devyn MitchelliD· 2 shared Lars PlateiD· 2 shared Andrew Michael GlazeriD· 1 shared Chai‐Ann NgiD· 1 shared Dan M. RodeniD· 1 shared Daniel J. BlackwelliD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersGenomics

Björn C. KnollmannORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsMolecular & Cellular ProteomicsPeer-reviewedSep 11, 2026

Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization

Christian L. Egly, Lea A. Barny, Suah Woo…·Brett M. Kroncke

This study links polygenic scores for QT interval to changes in Kv11.1 protein interactions in hiPSC-CMs, revealing connections between genetic variants and endocytic trafficking mechanisms.

DOI 10.1016/j.mcpro.2026.101656

humanproteomics

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BiochemistrybioRxivPreprintJan 31, 2024

The proteostasis interactomes of trafficking-deficient KV11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue

Christian L. Egly, Lea Barny, T. Q. Do…·Bjorn C. Knollmann

The paper identifies proteostasis interactomes of trafficking-deficient KV11.1 variants and shows pharmacological chaperone rescue of proteostasis network alterations in LQTS-associated variants.

DOI 10.1101/2024.01.31.574410

humanproteomics

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GeneticsHeart RhythmPeer-reviewedJun 6, 2020

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KCNH2

Krystian A. Kozek, Andrew Michael Glazer, Chai‐Ann Ng…·Brett M. Kroncke

This paper introduces a high-throughput method to screen KCNH2 variants for trafficking defects, validating it with multiple assays and showing its utility for identifying loss-of-function variants.

59 citationstop 3%

humanelectronic health records

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