Alexander R. Paredez

GlRac Regulates an ATG8-Independent Autophagy-Like Pathway in Giardia lamblia

This study identifies an ATG8-independent autophagy-like pathway in Giardia lamblia regulated by GlRac, showing structural and functional similarities to canonical autophagy despite lacking most ATG genes.

Unraveling the Role of cAMP Signaling in Giardia: Insights into PKA-Mediated Regulation of Encystation and Subcellular Interactions

This study investigates the role of cAMP signaling in Giardia, focusing on PKA-mediated regulation of encystation and subcellular interactions using Split-Halo technology.

Encystation stimuli sensing mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia

The paper shows that AC2-dependent cAMP signaling mediates encystation in Giardia lamblia in response to stimuli like bile and alkaline pH.

A cell cycle-dependent GARP-like transcriptional repressor regulates the initiation of differentiation in Giardia lamblia

This paper identifies GLP4, a GARP-like transcriptional repressor, as a key regulator of encystation initiation in Giardia lamblia by repressing MYB2 and encystation-specific genes during the G1+S phase of the cell cycle.