Lequan Yu

BLOOM generates developmental cell-expression distributions across time using conditional flow matching, outperforming baselines in gene and cell-expression correlations.

PertCurve models continuous transcriptional response trajectories from CRISPR screens, improving prediction of genetic modulations by capturing diverse perturbation strengths and downstream gene behaviors.

BRIDGE generates virtual spatial transcriptomes from histology images, improving cancer diagnosis accuracy in few-shot settings and outperforming existing models.

Hist2Cell predicts fine-grained transcriptional cell types from histology images with high accuracy, enabling cellular mapping and cancer prognosis.

SERM improves gene expression imputation in scRNA-seq data with higher accuracy and 100-fold faster computation than existing methods.