Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in mice
Trinovita Andraini, Lionel Moulédous, Petnoï Petsophonsakul, Cédrick Florian, Sébastien Lopez, Marlène Daloyau, Macarena S. Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Pelloquin, Pascale Belenguer, Claire Rampon, Marie‐Christine Miquel
This study shows that mitochondrial OPA1 deficiency in mice causes early spatial memory impairments linked to adult neurogenesis defects, which can be reversed by exercise or pharmacological treatment.
bioRxiv · Nov 16, 2021 · PreprintNeuroscience