Author

Macarena S. Arrázola

Centre National de la Recherche ScientifiqueORCID 0000-0002-0840-8997Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Adam Philip· 1 shared Alice Leydier· 1 shared Cédrick FlorianiD· 1 shared Claire RamponiD· 1 shared Douglas J. LamontiD· 1 shared Felipe A. CourtiD· 1 shared Felipe Véliz‐ValverdeiD· 1 shared Gabriel QuiroziD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Adam Philip

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2 papers

Recent·Most cited

Necroptosis inhibition counteracts neurodegeneration, memory decline and key hallmarks of aging, promoting brain rejuvenation.

Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Felipe Véliz‐Valverde, Somya Iqbal, Samantha L. Eaton, Rachel Kline, Douglas J. Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo F. Cerpa, Thomas M. Wishart, Felipe A. Court

This study shows that inhibiting necroptosis in aged mice reduces axonal degeneration, neuroinflammation, and memory decline, promoting brain rejuvenation.

Aging Cell · Mar 27, 2023Peer-reviewedNeuroscience

Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in mice

Trinovita Andraini, Lionel Moulédous, Petnoï Petsophonsakul, Cédrick Florian, Sébastien Lopez, Marlène Daloyau, Macarena S. Arrázola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Pelloquin, Pascale Belenguer, Claire Rampon, Marie‐Christine Miquel

This study shows that mitochondrial OPA1 deficiency in mice causes early spatial memory impairments linked to adult neurogenesis defects, which can be reversed by exercise or pharmacological treatment.

bioRxiv · Nov 16, 2021 · PreprintNeuroscience