Author

Joachim Fentz

Evotec (Germany)ORCID 0000-0002-9334-1298Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 1 shared Annette GärtneriD· 1 shared Antje Cornelius· 1 shared Ashley SummersiD· 1 shared C. Frank BennettiD· 1 shared Cassandra A. McHughiD· 1 shared Daniel O’ReillyiD· 1 shared David HowlandiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anastasia KhvorovaORCID

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1 paper

Recent·Most cited

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner, Jillian Belgrad, Robert M. Bragg, Daniel O’Reilly, Jeffrey P. Cantle, Cassandra A. McHugh, Ashley Summers, Joachim Fentz, Tom Schwagarus, Antje Cornelius, Ioannis Lingos, Zoe N. Burch, Marina V. Kovalenko, , Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

Nature Communications · Nov 14, 2025Peer-reviewedNeuroscience