Author

Annette Gärtner

Evotec (Germany)ORCID 0000-0001-6189-9679Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Deanna M. MarchioniniiD· 2 shared Paolo Beuzer· 2 shared Ricardo Mouro PintoiD· 2 shared Thomas VogtiD· 2 shared A.L. Bergander· 1 shared Alan MirandaiD· 1 shared Alexander Vogt· 1 shared Anastasia IllarionovaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Deanna M. MarchioniniORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 29, 2026

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

Judith Praena Fernandez, Annette Gärtner, Jesús Pérez‐Pérez…·Paolo Beuzer

The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.

DOI 10.64898/2026.07.29.741355

humanDNA methylation

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NeuroscienceNature CommunicationsPeer-reviewedNov 14, 2025

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner…·Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

14 citationstop 3%

mousestatistical model

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NeurosciencebioRxivPreprintJul 9, 2021

A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington's disease

Daniele Bertoglio, Jonathan Bard, Manuela Heßmann…·Ignacio Muñoz-Sanjuán

This paper develops a PET radioligand to visualize mutant huntingtin levels in the brain and assess therapeutic interventions in Huntington's disease.

2 citations

humanimaging

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