Author

Cassandra A. McHugh

Western Washington UniversityORCID 0009-0002-6184-3258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 2 shared Ashley SummersiD· 2 shared C. Frank BennettiD· 2 shared Daniel O’ReillyiD· 2 shared David HowlandiD· 2 shared Deanna M. MarchioniniiD· 2 shared Ella W. MathewsiD· 2 shared Hilary A. WilkinsoniD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Anastasia KhvorovaORCID

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3 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedNov 14, 2025

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner…·Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

14 citationstop 3%

mousestatistical model

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Molecular BiologyMolecular TherapyPeer-reviewedMay 11, 2023

Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington's Disease

Daniel O’Reilly, Jillian Belgrad, Chantal M. Ferguson…·Anastasia Khvorova

Silencing MSH3 in the CNS of two models of Huntington's disease using di-valent siRNA blocks disease-accelerating somatic expansion of CAG repeats.

60 citationstop 2%

mouseexperimental assay

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NeurosciencebioRxivPreprintJul 23, 2020

Huntingtin lowering reduces somatic instability at CAG-expanded loci

Sydney R. Coffey, Marissa A Andrew, Heather Ging…·Jeffrey B. Carroll

This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.

8 citations

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