Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly
Mandira Dutta, Kimberly A. Dolan, Souad Amiar, Elijah J. Bass, Rokaia Sultana, Sean M. Braet, Karen Johanna Cárdenas-Martínez, Devika Sirohi, Ian K. Hicklin, Richard J. Kuhn, Ganesh S. Anand, Gregory A. Voth, Stephen Graf Brohawn, Robert Virgil Stahelin
This study identifies a direct interaction between SARS-CoV-2 M protein and sphingolipids that regulates its conformational dynamics and virus assembly.
Nature Communications · Jul 23, 2026Peer-reviewedMicrobiology