Robert Virgil Stahelin

This study identifies a lipid-gated vesicular trafficking pathway for HSPA1A to the plasma membrane via the endo-lysosomal network, highlighting lysosomal BMP and endosomal PI(4)P as regulatory factors.

This study identifies a direct interaction between SARS-CoV-2 M protein and sphingolipids that regulates its conformational dynamics and virus assembly.

This study shows heat-induced phosphatidylserine (PS) increases drive HSPA1A's plasma membrane localization, with PS synthesis inhibition reducing this localization.

This study compares the conformational dynamics of native SARS-CoV-2 Spike protein in virus-like particles to recombinant Spike, finding reduced dynamics in VLP S and implications for epitope display.

This study uses computational methods to show that NP enhances VP40 VLP production by stabilizing filaments and accelerating budding, with optimal timing and expression ratios.

This paper evaluates the effect of fendiline on EBOV VP40 filament assembly using a computational model, finding it may temporarily increase VLP production but generally reduces it.

This study uses a computational model to investigate how phosphatidylserine influences VP40 matrix protein assembly in Ebola virus, showing PS affects filament growth and assembly steps.

This study identifies two lysine-rich regions in VP40 that bind PI(4,5)P2, stabilizing oligomers necessary for EBOV budding and assembly, with quercetin inhibiting this process.

This study shows that mutating cysteine residues in Ebola virus VP40 increases its binding to phosphatidylserine membranes, leading to longer virus-like particles and enhanced budding.