Ganesh S. Anand

This study isolates and structures native Pol II transcription complexes and nucleosomes from Drosophila embryos, revealing new insights into transcription dynamics and nucleosome interactions.

This study identifies a direct interaction between SARS-CoV-2 M protein and sphingolipids that regulates its conformational dynamics and virus assembly.

This paper investigates how the D614G mutation in SARS-CoV-2 spike protein alters conformational dynamics and allosteric communication, leading to faster RBD opening and increased infectivity.

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

This study identifies a fold switch in ONNV nsP4 that regulates its conformation, RNA binding, and polymerase activity through proteolytic cleavage and fold switching.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This study compares the conformational dynamics of native SARS-CoV-2 Spike protein in virus-like particles to recombinant Spike, finding reduced dynamics in VLP S and implications for epitope display.

This study shows that N153-linked glycans on dengue virus envelope protein help evade antibody-mediated clearance, with implications for immune evasion in related flaviviruses.

This study investigates how DENV2C chaperone activity facilitates strand displacement during RNA rearrangement without altering the structural functionality of the cHP hairpin element.

This study shows that DENV2C switches the annealing pathway and reduces the intrinsic dynamics of the 5UTR, aiding in RNA replication.