Xeno amino acid alphabets form peptides with familiar secondary structure
Sean M. Brown, Tadeáš Kalvoda, Robin Kryštůfek, Ján Michael Kormaník, Mikhail Makarov, Václav Verner, R. Hexnerova, Pavel Srb, Erik Andris, Lucie Bednářová, Markéta Pazderková, Martin Lepšı́k, Jan Řezáč, Jan Konvalinka, Václav Veverka, , Klára Hlouchová
The paper shows that peptides made from non-standard amino acids can form protein-like secondary structures, expanding the known sequence-structure space beyond Earth's 20 amino acids.
bioRxiv · Jan 31, 2026 · PreprintBiochemistry