Václav Veverka

This study investigates how the histone chaperone Spt6 regulates the H3K36 methyltransferase Set2 by relieving its autoinhibition, impacting transcription and H3K36 methylation.

The paper shows that peptides made from non-standard amino acids can form protein-like secondary structures, expanding the known sequence-structure space beyond Earth's 20 amino acids.

The paper designs ancient proteins using a limited amino acid set and shows they are stable and mutation-resilient.

This paper shows that the Spt6 N-terminal domain binds histones and controls chromatin structure, with its function conserved between yeast and humans.

The paper investigates the context-dependent roles of three Drosophila methyltransferases in H3K36 methylation and their implications for chromatin reader interactions.

This study shows how N-glycosylation modulates CD44's binding to hyaluronan by altering binding site affinity and promoting weaker interactions.

The paper models H3K36me3 marking dynamics, showing transcription-dependent placement dominates its establishment and turnover limits epigenetic memory.