Mikhail Makarov

Xeno amino acid alphabets form peptides with familiar secondary structure

The paper shows that peptides made from non-standard amino acids can form protein-like secondary structures, expanding the known sequence-structure space beyond Earth's 20 amino acids.

Coenzyme-Protein Interactions since Early Life

This study examines protein-coenzyme interactions in the Protein Data Bank to assess the plausibility of early peptide-cofactor collaborations before the Central Dogma.

Prebiotically Plausible Peptides can Self-assemble into beta-rich Assemblies

This study shows random 25-mer peptides with a prebiotically plausible amino acid alphabet can self-assemble into thermostable beta-rich nanostructures.

Peptides at vesicle and mineral prebiotic interfaces

This study investigates how peptides interact with mineral surfaces and lipid vesicles, showing acidic residues bind minerals and arginine enhances phosphate mobilization, while different amino acid alphabets affect vesicle stability.