Dynamics of chromatin accessibility during human first-trimester neurodevelopment
Camiel C. A. Mannens, Lijuan Hu, Peter Lönnerberg, Marijn Schipper, Caleb C. Reagor, Xiaofei Li, Xiaoling He, Roger A. Barker, Erik Sundström, Daniëlle Posthuma, Sten Linnarsson
The paper constructs a single-cell chromatin accessibility atlas of the human first trimester brain, identifies regulatory elements linked to gene expression, and links disease SNPs to potential pathogenic mechanisms.
bioRxiv · Aug 18, 2023 · PreprintDevelopmental Biology