Xiaoling He

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

Organotypic Timelapse recording with Transcriptomic Readout (OTTR) links cell behaviour to cell identity in human tissues

OTTR combines live imaging and spatial transcriptomics to link cell behavior to molecular states in human tissues.

Cell atlas of the developing human meninges reveals a dura origin of meningioma

The paper generates a single-cell and spatial transcriptomic atlas of human fetal meninges and finds that meningiomas likely originate from dura lineage cells.

Spatiotemporal map of the developing human reproductive tract at single-cell resolution

This study creates a single-cell spatial atlas of the developing human reproductive tract, identifying genes and mechanisms involved in sexual dimorphism and organ development.

A multiomic atlas of human early skeletal development

This study constructs a multiomic atlas of human early skeletal development using single-nuclei transcriptomics, epigenomics, and spatial transcriptomics to uncover regulatory mechanisms and cell states involved in bone and joint formation.

Developmental Dynamics of Human Cardiogenesis: A multi-omic reference and its disruption in Trisomy 21

This study develops a multi-omic reference of human cardiac development and identifies disruptions in Trisomy 21 hearts.

A human developing heart atlas reveals cardiovascular cell diversity for in vitro model benchmarking

The paper creates a high-resolution human developing heart atlas using single-cell and spatial transcriptomics, identifies new cell types, and benchmarks in vitro models.

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: implications for the STEM-PD clinical trial.

The paper assesses the immunogenicity of RC17 hESC-derived dopaminergic neural progenitor cells, finding they are immunosuppressive and similar to fetal tissue, suggesting reduced need for aggressive immunosuppression post-transplantation.

A human embryonic limb cell atlas resolved in space and time

This paper creates a human embryonic limb cell atlas using single-cell and spatial transcriptomics, identifying novel cell populations and developmental patterns.

Comprehensive cell atlas of the first-trimester developing human brain

This study creates a comprehensive cell atlas of the first-trimester human brain using single-cell RNA sequencing and spatial transcriptomics, identifying over 600 distinct cell states and their spatial organization.

Dynamics of chromatin accessibility during human first-trimester neurodevelopment

The paper constructs a single-cell chromatin accessibility atlas of the human first trimester brain, identifies regulatory elements linked to gene expression, and links disease SNPs to potential pathogenic mechanisms.

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

The paper constructs a human fetal lung cell atlas from 5-22 post conception weeks, identifying new cell states and regulators of epithelial fates.

Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.

RNA velocity in single cells

Unspliced versus spliced mRNA in standard scRNA-seq gives RNA velocity, a per-cell vector predicting future state over hours, validated in neural crest and used to trace mouse hippocampal lineages.