Xiaofei Li

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

Spatial Dynamics of the Developing Human Heart

This study maps spatial dynamics in early human heart development using single-cell and spatial transcriptomics, identifying cell states and novel features like cardiac fibroblasts and chromaffin cells.

Organotypic Timelapse recording with Transcriptomic Readout (OTTR) links cell behaviour to cell identity in human tissues

OTTR combines live imaging and spatial transcriptomics to link cell behavior to molecular states in human tissues.

Activation of Endogenous Spinal Cord Stem Cell Mediates Recovery Induced by Olfactory Ensheathing Cell Transplantation Following Spinal Cord Injury

This study shows that olfactory ensheathing cell transplantation promotes spinal cord recovery by activating endogenous ependymal cells, enhancing their proliferation and supporting axonal growth.

Alzheimer's Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain Development

This study shows AD mutations impair neural stem cell fate and early brain development, leading to structural vulnerabilities that may increase AD risk later in life.

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

The paper introduces DeepCellMap, a deep learning tool for analyzing spatial cellular organization in developing brains, revealing microglial phenotypes and spatial clustering patterns.

Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology

This study profiles cell-type specific changes in human entorhinal cortex at early Alzheimer's disease stages, identifying dysregulation of Reelin signaling and downregulation of NPTX2 and CBLN4.

Whole-Brain Three-Dimensional Imaging of RNAs at Single-Cell Resolution

The paper develops TRIC-DISCO, a pipeline for whole-brain 3D RNA imaging in adult mice, enabling single-cell resolution of transcriptional signatures and markers without strict RNase-free conditions.

High-parametric protein maps reveal the spatial organization in early-developing human lung

This study maps the spatial organization of the developing human lung using high-parametric protein imaging, revealing cell type composition and temporal changes across five developmental timepoints.

Comprehensive cell atlas of the first-trimester developing human brain

This study creates a comprehensive cell atlas of the first-trimester human brain using single-cell RNA sequencing and spatial transcriptomics, identifying over 600 distinct cell states and their spatial organization.

Dynamics of chromatin accessibility during human first-trimester neurodevelopment

The paper constructs a single-cell chromatin accessibility atlas of the human first trimester brain, identifies regulatory elements linked to gene expression, and links disease SNPs to potential pathogenic mechanisms.

Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin

The paper creates a developmental cell atlas of the human spinal cord using single-cell and spatial transcriptomics, revealing spatiotemporal gene regulation and novel insights into ependymoma cancer stem cells.

Developmental origins of cell heterogeneity in the human lung

The paper creates a comprehensive topographic atlas of early human lung development, identifying cell states, trajectories, and interactions to understand cell heterogeneity origins.

A Landmark-based Common Coordinate Framework for Spatial Transcriptomics Data

The paper introduces a method to align spatial transcriptomics data into a common coordinate framework and demonstrates its application on real and synthetic datasets.