Methyl-substituted 1,10-phenanthroline derivatives in copper(II) complexes enhance antitumor activity and inhibit NHE1 in MDA-MB-231 breast cancer cells
Katherine Seneth Muñoz Garzón, Verónica Celeste De Giusti, Carlos Yañez Fernandez, Gianella Facchin, V. Martínez, Ana Laura Di Virgilio
This study evaluates three copper(II) complexes with methyl-substituted phenanthroline ligands, showing enhanced antitumor activity against breast cancer cells through ROS-mediated apoptosis and NHE1 inhibition.
bioRxiv · Sep 9, 2026 · PreprintCell Biology