Yutaka Sakai

Hippocampal sharp-wave ripples decrease during physical actions including consummatory behavior in immobile rodents

This study shows that hippocampal sharp-wave ripples (SWRs) decrease during physical actions and consummatory behavior in immobile rats, challenging the idea that SWRs are specific to consummation.

Continuous Neural Correlates of Imbalanced Reinforcement Learning in Obsessive-Compulsive Disorder and Healthy Individuals

The paper identifies a neural network with increased functional connectivity in OCD patients and a subgroup of healthy individuals with imbalanced reinforcement learning.

Synaptic tagging and capture underlie neuronal co-allocation and temporal association memory in behaving mice

This study demonstrates synaptic tagging and capture (STC) mechanisms in behaving mice, showing that coactive neurons benefit from temporally proximate protein synthesis for memory consolidation.

Hippocampal CA1 represents action and reward events instantly compared to the superficial and deep layers of the lateral entorhinal cortex

The paper compares the timing of action and reward event representation in hippocampal CA1 and lateral entorhinal cortex layers during operant learning in rats.

Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia

The paper investigates how dopamine systems in the basal ganglia process reward prediction based on working memory versus random rewards in rats and mice.

Automated and parallelized spike collision tests to identify spike signal projections

This paper introduces Multi-Linc analysis, an automated method for parallel spike collision tests to identify neuronal projections, demonstrating its application in rat cortical neurons.

Memory Trace Imbalance in Reinforcement and Punishment Systems Can Reinforce Implicit Choices Leading to Obsessive-Compulsive Behavior

This study models OCD as implicitly learned maladaptive behaviors in reinforcement learning, showing imbalanced memory traces for positive and negative prediction errors, and links this imbalance to OCD symptoms and therapeutic responses.