Opioidergic activation of descending pain inhibitory system underlies placebo analgesia
Hiroyuki Neyama, Yuping Wu, Yuka Nakaya, Shigeki Kato, Tomoko Shimizu, Tsuyoshi Tahara, Mika Shigeta, Michiko Inoue, Kazunari Miyamichi, Natsuki Matsushita, Tomoji Mashimo, Yoshiki Miyasaka, Yi Dai, Koichi Noguchi, Yasuyoshi Watanabe, , Yilong Cui
The paper shows that opioidergic signals in the medial prefrontal cortex activate the descending pain inhibitory system to initiate placebo analgesia in neuropathic pain rats.
Science Advances · Jan 15, 2025Peer-reviewedNeuroscience