Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal M. Mrug, Brittany N. Lasseigne
The paper identifies drug targets and repurposing candidates for ADPKD by analyzing gene expression signatures from mouse Pkd2 models using signature reversion.
bioRxiv · Dec 2, 2022 · PreprintGenomics