Timothy C. Howton

The paper evaluates changes in glia-neuron communication in 3xTg-AD mice hippocampus at 6 and 12 months, finding increased dysregulation and 23 AD-associated ligand-receptor pairs.

The paper identifies cell-type-specific alternative splicing changes in the cerebral cortex and kidney of Setbp1S858R mice, with implications for Schinzel-Giedion Syndrome.

The paper uses long-read RNA sequencing to analyze C57BL/6J mouse brain isoform expression and identifies region- and sex-specific alternative splicing patterns.

The paper identifies altered glia-neuron communication in Alzheimer's disease using snRNA-seq, revealing dysregulation of WNT, p53, and NFkB signaling in inhibitory neurons.

The paper identifies drug repurposing candidates for low-survival cancers by prioritizing drugs that reverse disease-associated gene signatures using three methods.

The paper analyzes SETBP1 gene expression and transcription factor activity across 31 human tissues using GTEx data, identifying tissue-specific patterns and providing a web tool for exploration.

This study uses snRNA-seq to analyze gene expression and regulatory changes in atypical SGS mice, revealing cell-type-specific effects of SETBP1 variants in the cerebral cortex and kidney.

The paper identifies drug targets and repurposing candidates for ADPKD by analyzing gene expression signatures from mouse Pkd2 models using signature reversion.