BioengineeringMolecular TherapyPeer-reviewed
Virus-free CRISPR knock-in of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells
Keerthana Shankar, Isabelle Zingler-Hoslet, Diana Marcela Tabima…·Krishanu Saha
This study uses CRISPR to disrupt an inhibitory receptor in NK cells and insert a GD2-targeting CAR, creating potent NK cells against GD2+ melanoma.
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