Author

Kirstan Gimse

University of Wisconsin–MadisonORCID 0000-0002-3548-3634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Krishanu SahaiD· 2 shared Subhojit RoyiD· 2 shared Anjon AudhyaiD· 1 shared Brent D. AulstoniD· 1 shared Cathleen M. LutziD· 1 shared Donald P. PizzoiD· 1 shared Dongdong LiiD· 1 shared Enikö A. KramáriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Krishanu SahaORCID

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2 papers

Recent·Most cited

Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus.

Brent D. Aulston, Kirstan Gimse, Hannah Bazick, Enikö A. Kramár, Donald P. Pizzo, Farbod Shavarebi, Trinity Rust, Sheila Garcia Rosa, Leonardo A Parra‐Rivas, Jichao Sun, Kristen Branes‐Guerrero, Nidhi Checka, Neda Bagheri, Sara B. Rosenthal, Nihal Satyadev, , Subhojit Roy

The paper uses CRISPR-Cas9 to edit the App gene in mice, reducing Alzheimer's disease symptoms and showing long-term benefits.

bioRxiv · Jun 8, 2024 · PreprintNeuroscience

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, , Shaoqin Gong

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.

bioRxiv · Jul 24, 2022Neuroscience