The paper investigates the genetic diversity of the SRA gene in T. b. rhodesiense isolates and APOL-1 genotypes in Malawian r-HAT patients, finding heterozygosity in SRA and severe r-HAT cases in APOL-1 G2 individuals.

DOI 10.1101/2024.09.07.611819

statistical model

GeneticsPLoS neglected tropical diseasesPeer-reviewedDec 6, 2023

Distinct Differences in Gene Expression Profiles in Early and Late Stage Rhodesiense HAT Individuals in Malawi

Peter Nambala, Julius Mulindwa, Harry A. Noyes…·Janelisa Musaya

This study compares gene expression profiles between early and late stage r-HAT patients in Malawi, identifying differentially expressed genes and potential diagnostic biomarkers.

2 citations

humanbulk RNA-seq

GenomicsbioRxivPreprintJul 11, 2023

Transcriptome profiles of T.b. rhodesiense parasites in Malawi reveal focus specific gene expression Profiles associated with pathology

Peter Nambala, Harry A. Noyes, Joyce Namulondo…·Julius Mulindwa

The paper analyzes transcriptome profiles of T.b. rhodesiense isolates from two Malawi foci, finding focus-specific gene expression patterns linked to disease severity and population structure.

DOI 10.1101/2023.07.11.548495

bulk RNA-seqstatistical model

GenomicsbioRxivPreprintJun 13, 2023

Transcriptome analysis of peripheral blood of Schistosoma mansoni infected children from the Albert Nile region in Uganda reveals genes implicated in fibrosis pathology.

Joyce Namulondo, Oscar A. Nyangiri, Magambo Phillip Kimuda…·Julius Mulindwa

This study analyzes RNA-seq data from Ugandan children infected with Schistosoma mansoni to identify differentially expressed genes associated with infection intensity and fibrosis-related pathways.

DOI 10.1101/2023.06.13.544714

humanbulk RNA-seq