Annette MacLeod

GENETIC DIVERSITY OF T. B. RHODESIENSE SERUM RESISTANCE ASSOCIATED GENE IN MALAWIAN ISOLATES

The paper investigates the genetic diversity of the SRA gene in T. b. rhodesiense isolates and APOL-1 genotypes in Malawian r-HAT patients, finding heterozygosity in SRA and severe r-HAT cases in APOL-1 G2 individuals.

A Genome-Wide Association Study Reveals Novel Genetic Markers Associated with Human African Trypanosomiasis

Murine trypanosomiasis recapitulates transcriptomic features of acute kidney injury

This study shows that Trypanosoma brucei infection in mice causes kidney injury with transcriptomic features similar to acute kidney injury.

APOL1 variants affect APOL1 plasma protein concentration: a UK Biobank study

This study uses UK Biobank data to show APOL1 genotype strongly influences plasma APOL1 levels, with Black or Black British individuals having higher levels despite genetic variation.

Distinct Differences in Gene Expression Profiles in Early and Late Stage Rhodesiense HAT Individuals in Malawi

This study compares gene expression profiles between early and late stage r-HAT patients in Malawi, identifying differentially expressed genes and potential diagnostic biomarkers.

Transcriptome profiles of T.b. rhodesiense parasites in Malawi reveal focus specific gene expression Profiles associated with pathology

The paper analyzes transcriptome profiles of T.b. rhodesiense isolates from two Malawi foci, finding focus-specific gene expression patterns linked to disease severity and population structure.

FISHtoFigure: An easy-to-use tool for rapid, multi-target partitioning and analysis of sub-cellular mRNA transcripts in smFISH data

FISHtoFigure is a software tool for analysing smFISH data, enabling automated spatial analysis of mRNA expression without requiring bioinformatics expertise.

Phenome-wide analysis of APOL1 risk variants reveals associations between one combination of haplotypes and multiple disease phenotypes in addition to chronic kidney disease

This study identifies non-kidney disease associations with APOL1 G1/G2 compound heterozygosity and reveals distinct effects of G1 and G2 homozygosity on kidney-related outcomes.

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d’Ivoire

This paper investigates genetic associations with susceptibility to Human African Trypanosomiasis in Côte d’Ivoire using a candidate gene approach and finds suggestive but non-significant associations in several immune-related genes.

Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa

The paper analyzes 289 genome sequences from Nilo-Saharan and Niger-Congo populations to identify population-specific selection signatures linked to disease resistance.

T cell activation and the HLA locus associate with latent infections of human African trypanosomiasis

The paper identifies genetic factors and immune mechanisms associated with symptom severity in human African trypanosomiasis using transcriptome analysis and an animal model.