Author

Anne K Linden

Northwestern UniversityORCID 0000-0002-9434-6103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chian‐Yu PengiD· 3 shared John A. KessleriD· 3 shared Aimee J. AylwardiD· 1 shared Amira AffanehiD· 1 shared Jessie CheniD· 1 shared Stephanie Van Gulden· 1 shared Yung‐Hsu TsaiiD· 1 shared Yvette C. WongiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 17 mutual co-author links

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3 shared papersNeuroscience

Chian‐Yu PengORCID

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3 papers

Recent·Most cited

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimers Disease Pathologies in Neurons

Anne K Linden, Amira Affaneh, Aimee J. Aylward, Yvette C. Wong, John A. Kessler, Chian‐Yu Peng

This study shows that BMP signaling enhances APOE4-induced lipid metabolic dysfunctions in astrocytes, leading to increased neuronal tau phosphorylation and reduced survival.

bioRxiv · Dec 14, 2025 · PreprintNeuroscience

Identification of Human Pluripotent Stem Cell Derived Astrocytic Progenitors that Correlate with Glioblastoma Subtypes

Stephanie Van Gulden, Anne K Linden, John A. Kessler, Chian‐Yu Peng

The paper identifies hPSC-derived astrocytic progenitors with gene expression profiles matching GBM subtypes and reveals molecular pathways associated with these progenitors.

bioRxiv · Aug 26, 2025 · PreprintDevelopmental Biology

YAP and TAZ differentially regulate postnatal cortical progenitor proliferation and astrocyte differentiation

Jessie Chen, Yung‐Hsu Tsai, Anne K Linden, John A. Kessler, Chian‐Yu Peng

This study shows TAZ and YAP have distinct roles in regulating astrocyte differentiation and NPC proliferation through different signaling pathways.

Journal of Cell Science · Apr 19, 2024Peer-reviewedNeuroscience