Author

Amira Affaneh

Northwestern UniversityORCID 0000-0002-0149-3391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

John A. KessleriD· 2 shared Adriana FerreiraiD· 1 shared Aimee J. AylwardiD· 1 shared Alexis D. RickmaniD· 1 shared Andrea E. MurmanniD· 1 shared Anne K LindeniD· 1 shared Ashley Haluck-KangasiD· 1 shared Bidur PaudeliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

John A. KesslerORCID

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2 papers

Recent·Most cited

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimers Disease Pathologies in Neurons

Anne K Linden, Amira Affaneh, Aimee J. Aylward, Yvette C. Wong, John A. Kessler, Chian‐Yu Peng

This study shows that BMP signaling enhances APOE4-induced lipid metabolic dysfunctions in astrocytes, leading to increased neuronal tau phosphorylation and reduced survival.

bioRxiv · Dec 14, 2025 · PreprintNeuroscience

Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Peña-Martinez, Alexis D. Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Joy Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, , Marcus E. Peter

The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.

bioRxiv · Sep 8, 2022 · PreprintNeuroscience