Author

Aimee J. Aylward

Brigham and Women's HospitalORCID 0000-0002-8463-1904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Tracy L. Young‐PearseiD· 2 shared Adrian R. OrszulakiD· 1 shared Allison KnuppiD· 1 shared Amira AffanehiD· 1 shared Anne K LindeniD· 1 shared Benjamin P. Readhead· 1 shared Cheryl PaniD· 1 shared Chian‐Yu PengiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenomics

Tracy L. Young‐PearseORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer's disease

Meagan N. Olson, Pepper Dawes, Liam F. Murray, Nathaniel Barton, Jonathan Sundstrom, Adrian R. Orszulak, Samantha M. Chigas, Khanh Tran, Aimee J. Aylward, Michele F. Caliandro, Sean‐Patrick Riechers, Khashayar Afshari, Qi Wang, Manuel G. Garber, Fiachra Humphries, , Elaine T. Lim

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

npj Dementia · Mar 9, 2026Peer-reviewedGenomics

Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimers Disease Pathologies in Neurons

Anne K Linden, Amira Affaneh, Aimee J. Aylward, Yvette C. Wong, John A. Kessler, Chian‐Yu Peng

This study shows that BMP signaling enhances APOE4-induced lipid metabolic dysfunctions in astrocytes, leading to increased neuronal tau phosphorylation and reduced survival.

bioRxiv · Dec 14, 2025 · PreprintNeuroscience

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1

Hyo Lee, Aimee J. Aylward, Richard V. Pearse, Yi‐Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc Minh Duong, Nicholas T. Seyfried, David Alan Bennett, Hans‐Ulrich Klein, Philip L. De Jager, , Tracy L. Young‐Pearse

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

bioRxiv · Feb 25, 2023 · PreprintNeuroscience