Immortalised hippocampal astrocytes from 3xTG-AD mice fail to support BBB integrity in vitro: Role of extracellular vesicles in glial-endothelial communication
Karolina Kriaučiūnaitė, Aida Kaušylė, Justina Pajarskienė, Virginijus Tunaitis, Dmitry Lim, Alexei Verkhratsky, Augustas Pivoriūnas
This study shows that astrocytes from 3xTG-AD mice impair BBB integrity in vitro through paracrine mechanisms, as evidenced by reduced tight junction protein expression and TEER.
Cellular and Molecular Neurobiology · May 21, 2020Peer-reviewedNeuroscience