Per1/Per2-Igf2 axis-mediated circadian regulation of myogenic differentiation
Nobuko Katoku-Kikyo, Ellen Paatela, Daniel L. Houtz, Britney Lee, Dane Munson, Xuerui Wang, Mohammed Hussein, Jasmeet Bhatia, Seunghyun Lim, Ce Yuan, Yoko Asakura, Atsushi Asakura, Nobuaki Kikyo
This study shows that Per1 and Per2 regulate myoblast differentiation and muscle regeneration through Igf2 activation, creating a circadian time window for these processes.
The Journal of Cell Biology · Apr 27, 2021Peer-reviewedDevelopmental Biology