Experimental conditions to retrieve intrinsic cooperativity α directly from single binding assay data exemplified by the ternary complex formation of FKBP12, MAPRE1 and macrocyclic molecular glues
Jan Schnatwinkel, Richard R. Stein, Michael Salcius, Julian L. Wong, Shuyu Chen, Marianne Fouché, H.‐J. ROTH
This paper demonstrates how to directly measure intrinsic cooperativity from single binding assays using ternary complex formation between FKBP12, MAPRE1, and macrocyclic molecular glues.
International Journal of Molecular Sciences · Mar 24, 2025Peer-reviewedBiochemistry