Cancer BiologyiSciencePeer-reviewed
Human lung explants as a predictive platform for evaluating the on-target, off-tumor toxicity of T cell bispecifics
Manuel Tschan, Tania Jetzer, Melanie Obenloch…·Matthias P. Lütolf
This paper establishes a human lung explant model to quantify T cell bispecifics' on-target, off-tumor toxicity by measuring T cell activation and epithelial cell killing.
DOI 10.1016/j.isci.2026.117631