Single-sequence protein structure prediction using language models from deep learning
Ratul Chowdhury, Nazim Bouatta, Surojit Biswas, Christina Floristean, Anant Kharkar, Koushik Roy, Charlotte Rochereau, Gustaf Ahdritz, Joanna T. Zhang, George McDonald Church, Peter Karl Sorger, Mohammed AlQuraishi
This paper introduces RGN2, a deep learning model that predicts protein structure from single sequences without MSAs, outperforming AlphaFold2 and RoseTTAFold on orphan proteins and achieving faster computation.
Nature Biotechnology · Oct 3, 2022Peer-reviewedBioinformatics