Author

Aris A. Polyzos

Lawrence Berkeley National LaboratoryORCID 0000-0002-9542-5807Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

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Ana W. Y. CheongiD· 1 shared Cynthia T. McMurrayiD· 1 shared Jung Hyun Yoo· 1 shared Lana BlageciD· 1 shared Zachary David NageliD· 1 shared

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Ana W. Y. CheongORCID

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Recent·Most cited

Molecular BiologybioRxivPreprintMay 27, 2025

Double strand breaks drive toxicity in Huntington's disease mice with or without somatic expansion.

Aris A. Polyzos, Ana W. Y. Cheong, Jung Hyun Yoo…·Cynthia T. McMurray

This study shows that double strand breaks (DSBs) independently drive Huntington's disease toxicity in mice, separate from somatic expansion, and that inhibiting DSBs can reverse neuronal toxicity.

1 citation

mouseexperimental assay

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