Zachary David Nagel

This study shows MUTYH prevents telomere shortening and genomic instability in cancer cells under chronic 8-oxoG damage by resolving BER intermediates.

MSIanalyzer uses targeted nanopore sequencing to analyze microsatellite instability at single-nucleotide resolution, revealing distinct repeat profiles and allelic diversity in cancer cell lines.

This study develops a model using stem-like cells to study how glioblastoma evolves resistance to therapy.

This study shows that double strand breaks (DSBs) independently drive Huntington's disease toxicity in mice, separate from somatic expansion, and that inhibiting DSBs can reverse neuronal toxicity.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

This study identifies ATM phosphorylation of DNA-PKcs at T4102 as critical for stabilizing NHEJ machinery and promoting DSB repair.