Nuclear actin-dependent Meg3 expression suppresses metabolic genes by affecting the chromatin architecture at sites of elevated H3K27 acetylation levels
Nadine Hosny El Said, Wael Said Abdrabou, Syed Raza Mahmood, Tomáš Venit, Youssef Idaghdour, Piergiorgio Percipalle
This study shows that β-actin depletion increases Meg3 expression, which alters chromatin architecture and represses metabolic genes through promoter-enhancer interaction disruption.
Nucleic Acids Research · Mar 31, 2025Peer-reviewedMolecular Biology