Tomáš Venit

Nuclear Myosin VI stabilises Ku-associated DNA ends during non-homologous end joining

This study identifies myosin VI as a regulator of DNA double-strand break repair, linking ATM signalling to Ku-associated DNA-end stabilisation and suggesting potential therapeutic targeting.

Nuclear Myosin 1 links genomic architecture to adipose tissue remodeling, metabolic inflammation and obesity in mice

This study shows NM1 regulates adipose tissue remodeling, metabolic inflammation, and obesity in mice by controlling chromatin accessibility and gene expression during adipogenesis.

Nuclear actin-dependent Meg3 expression suppresses metabolic genes by affecting the chromatin architecture at sites of elevated H3K27 acetylation levels

This study shows that β-actin depletion increases Meg3 expression, which alters chromatin architecture and represses metabolic genes through promoter-enhancer interaction disruption.

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture

This study shows that β-actin levels influence chromatin remodeling activities and 3D genome architecture in mouse embryonic fibroblasts.