OctopusV and TentacleSV provide a toolkit for multi-sample, cross-platform structural variant analysis, improving precision and consistency in cancer genomics and rare disease diagnostics.

Bioinformatics · Oct 30, 2025Peer-reviewedBioinformatics

A Genomic Language Model for Chimera Artifact Detection in Nanopore Direct RNA Sequencing

Yangyang Li, Ting-You Wang, Qing‐Xiang Guo, Yanan Ren, Xiaotong Lu, Qi Cao, Rendong Yang

Deep-Chopper detects and removes adapter sequences from nanopore dRNA-seq reads, improving transcriptome analysis accuracy.

bioRxiv · Oct 23, 2024 · PreprintGenomics

Region- and variance-based DNA methylation analyses reveal novel disease genes and pathways for systemic lupus erythematosus

Mengbiao Guo, Ting-You Wang, Jiangshan Jane Shen, Yongfei Wang, YL Lau, Wanling Yang

The paper identifies disease genes and pathways in systemic lupus erythematosus by analyzing DNA methylation differences in blood cells, finding distinct patterns in T and B cells.

bioRxiv · Nov 23, 2022 · PreprintBioinformatics

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity that may underly population disparities in this disease

Yongfei Wang, Yan Zhang, Zhiming Lin, Huoru Zhang, Ting-You Wang, Yujie Cao, David Lester Morris, Yujun Sheng, Xianyong Yin, Shi-Long Zhong, Xiaoqiong Gu, Lei Yao, Jing He, Qi Wu, Jiangshan Jane Shen, , Wanling Yang

This study identifies 38 novel SLE loci and shows genetic heterogeneity across ancestral groups, highlighting antibody production as a potential mechanism for disease disparities.

Nature Communications · Feb 3, 2021Peer-reviewedGenetics