Author

Mark N. Lee

Broad InstituteORCID 0000-0002-9576-9589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Alexandra–Chloé VillaniiD· 1 shared Aviv RegeviD· 1 shared Barbara E. StrangeriD· 1 shared Benjamin Y. LuiD· 1 shared Berkay YahsiiD· 1 shared Chun YeiD· 1 shared Cristin AubiniD· 1 shared David A. SchoenfeldiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperGenomics

Alexandra–Chloé VillaniORCID

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3 papers

Recent·Most cited

Phenotypic and functional characterization of tumor-reactive T cells in malignant pleural effusions

Noam Savion‐Gaiger, Jack Coburn, Mark N. Lee, Lin Zhang, HENG-LE CHEN, Gavitt Alida Woodard, Harriet M. Kluger, David A. Schoenfeld, Benjamin Y. Lu

This study characterizes T cells in malignant pleural effusions (MPE) and finds they have lower exhaustion and higher cytotoxic potential compared to tumor T cells, suggesting MPE as a better source for TIL therapy.

Cancer Immunology Research · Sep 11, 2026Peer-reviewedImmunology

De novo identification of the specificities of recurrent human T cell receptors

Mithila Kasbe, Berkay Yahsi, Kalyn Whitehead, Jiwon Oh, Mashwiyat Mosharraf, Kayla Sohn, Trinh Phan, Mark N. Lee

The paper identifies antigen specificities of public TCRs by screening TCR panels against viral genomes and reference strains, revealing cross-reactive TCRs against coronaviruses, influenza, and herpesviruses.

bioRxiv · Aug 3, 2025 · PreprintImmunology

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

Chun Ye, Jenny Chen, Alexandra–Chloé Villani, Rachel E. Gate, Meena Subramaniam, Tushar Bhangale, Mark N. Lee, Towfique Raj, Raktima Raychowdhury, Weibo Li, Noga Rogel, Sean Simmons, Selina H. Imboywa, Portia I. Chipendo, Cristin Aubin, , Nir Hacohen

The paper identifies genetic variants influencing isoform usage in the anti-viral response, revealing ERAP2's role in balancing selection and influenza-specific regulation.

Genome Research · Dec 1, 2018Peer-reviewedGenomics