Environment constrains fitness advantages of division of labor in microbial consortia engineered for metabolite push or pull interactions
Ashley E. Beck, Kathryn Pintar, Diana R. Schepens, Ashley Schrammeck, Timothy Johnson, Alissa C. Bleem, Martina Du, William R. Harcombe, Hans Christopher Bernstein, Jeffrey J. Heys, Tomáš Gedeon, Ross P. Carlson
The paper tests how environmental conditions affect the fitness of microbial consortia with different metabolite exchange strategies, finding that a lactic acid-exchanging consortium outperformed wild type under weakly buffered conditions but not under highly buffered conditions.
mSystems · Jun 28, 2022Peer-reviewedSynthetic Biology