Hans Christopher Bernstein

Fine Tuning Genetic Circuits via Host Context and RBS Modulation

This study fine-tunes a genetic toggle switch by varying host contexts and ribosome binding sites to optimize performance metrics like signaling strength and inducer sensitivity.

Pangenomic Landscapes Shape Performances of a Synthetic Genetic Circuit Across Stutzerimonas Species

The paper investigates how genome structure and function influence the performance of a synthetic genetic circuit across six Stutzerimonas species, revealing that core genome expression drives observed differences.

Revealing the chassis-effect on a broad-host-range genetic switch and its concordance with interspecies bacterial physiologies

This study investigates the chassis-effect in genetic switches across bacterial hosts, finding that physiological similarity correlates with toggle switch performance.

Environment constrains fitness advantages of division of labor in microbial consortia engineered for metabolite push or pull interactions

The paper tests how environmental conditions affect the fitness of microbial consortia with different metabolite exchange strategies, finding that a lactic acid-exchanging consortium outperformed wild type under weakly buffered conditions but not under highly buffered conditions.

A broad-host-range event detector: expanding and quantifying performance across bacterial species

This study evaluates a chemical event logger's performance across different bacterial species, finding that Pseudomonads outperform E. coli in some aspects.

Lactobacillus acidophilus disrupts collaborative multispecies bile acid metabolism

This study investigates how Lactobacillus acidophilus affects microbial interactions in bile acid metabolism, revealing it inhibits the production of ursocholate, which correlates with weight loss after gastric bypass.