The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes
Olha M. Koval, Emily K. Nguyen, Dylan J. Mittauer, Karima Ait‐Aissa, William C. Chinchankar, Lan Qian, Muniswamy Madesh, Dao‐Fu Dai, Isabella M. Grumbach
This study investigates how mitochondrial dysfunction in T2D drives VSMC proliferation through Ca2+ regulation and Erk1/2 activation, showing that mtCaMKII inhibition reduces proliferation and neointima formation.
bioRxiv · Feb 15, 2023 · PreprintMolecular Biology