Isabella M. Grumbach

Late radiation-induced brain injury is associated with functional cerebrovascular impairment without structural vessel loss in mice

This study shows that late radiation-induced brain injury in mice causes functional cerebrovascular impairment without structural vessel loss, highlighting endothelial dysfunction as a key factor.

Long-Term Effects of Radiation Therapy on Cerebral Microvessel Proteome: A Six-Month Post-Exposure Analysis

This study identifies significant proteomic changes in cerebral microvessels six months after radiation therapy, linking them to metabolic dysfunction and potential cognitive impairment.

MIRO1 controls energy production and proliferation of vascular smooth muscle cells

This study shows MIRO1 regulates VSMC proliferation and neointima formation by controlling mitochondrial positioning, ATP production, and ETC function.

The mitochondrial regulation of smooth muscle cell proliferation in type 2 diabetes

This study investigates how mitochondrial dysfunction in T2D drives VSMC proliferation through Ca2+ regulation and Erk1/2 activation, showing that mtCaMKII inhibition reduces proliferation and neointima formation.