Kevin Brick

High resolution maps of chromatin reorganization through mouse meiosis reveal novel features of the 3D meiotic structure

The paper maps chromatin reorganization during mouse meiosis at high resolution, revealing novel features of 3D meiotic structure and the role of CTCF in loop anchoring.

Germline DNA replication shapes the recombination landscape in mammals

The paper investigates how meiotic DNA replication patterns influence recombination landscapes in mammals, finding a strong correlation between replication origin density and recombination potential.

Ensuring meiotic DNA break formation in the mouse pseudoautosomal region

The paper identifies cis- and trans-acting factors that drive meiotic DNA break formation in the mouse pseudoautosomal region, revealing structural and molecular mechanisms essential for recombination and segregation.

Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis

The paper develops a method to isolate meiotic nuclei and reveals dynamic histone modification changes during meiotic prophase I in mammals.

REC114 partner ANKRD31 controls number, timing and location of meiotic DNA breaks

This study identifies ANKRD31 as a regulator of meiotic DNA break formation in mice, showing its role in controlling DSB number, timing, and location, and linking its dysfunction to infertility.

Extensive sex differences at the initiation of genetic recombination

The paper maps meiotic DSBs in male and female mice, showing sex differences in DSB initiation and repair, linked to aneuploidy rates.