Mehmet E. Karasu

CCAR1 promotes DNA repair via an unanticipated role in alternative splicing

The paper identifies CCAR1 as a splicing fidelity factor that regulates alternative splicing of FANCA and other genes, impacting DNA repair processes.

TREX1 restricts CRISPR-Cas9 genome editing in human cells

The paper identifies TREX1 as a suppressor of CRISPR-Cas9 HDR efficiency in human cells and shows that TREX1 removal or use of chemically protected templates can enhance HDR.

Adenine base editing is an efficient approach to restore function in FA patient cells without double-stranded DNA breaks

This study demonstrates that adenine base editing can restore FANCA function in FA patient cells without causing DNA breaks, showing promise for therapeutic applications.

Ensuring meiotic DNA break formation in the mouse pseudoautosomal region

The paper identifies cis- and trans-acting factors that drive meiotic DNA break formation in the mouse pseudoautosomal region, revealing structural and molecular mechanisms essential for recombination and segregation.

Cyclin B3 is dispensable for mouse spermatogenesis

This study shows that cyclin B3 is not required for male meiosis despite its meiosis-specific expression, as male mice lacking cyclin B3 are fertile with normal spermatogenesis.

REC114 partner ANKRD31 controls number, timing and location of meiotic DNA breaks

This study identifies ANKRD31 as a regulator of meiotic DNA break formation in mice, showing its role in controlling DSB number, timing, and location, and linking its dysfunction to infertility.