Cancer BiologybioRxivPreprint
C1q from C1q+ tumor-associated myeloid cells promotes resistance to T-cell engagers and CAR T-cells and is induced by LIF and glucocorticoids
María López Vázquez, Sergio Espinosa-Gil, Raffaella Iurlaro…·Joan Seoane
This study identifies C1q from C1q+ tumor-associated myeloid cells as a key immunosuppressive factor in glioblastoma that impairs T-cell engagers and CAR T-cell efficacy, induced by LIF and glucocorticoids.