Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Bharat Kundaje, Jin Billy Li
The paper develops a CRISPR-based mutagenesis approach combined with machine learning to model cis-regulatory features of ADAR-mediated RNA editing, explaining over 70% of editing level variation.
Nature Communications · Apr 12, 2021Peer-reviewedMolecular Biology