Jin Billy Li

This study shows ADAR1p150 suppresses immunogenicity from tonic type I IFN-induced transcripts through editing-dependent and -independent mechanisms.

The paper links ADAR1-mediated RNA editing in smooth muscle cells to regulation of MDA5 activation, showing its role in atherosclerosis progression and vascular calcification.

This study identifies a conserved A-to-I RNA editing site in Drosophila GluClα essential for olfactory behaviors and social interactions.

The paper shows that ADAR1p150 prevents MDA5 and PKR activation through distinct mechanisms, preventing fatal autoinflammation.

The paper identifies developmentally regulated alternative 3' end cleavage of transcripts in Drosophila spermatogenesis, showing how it affects protein expression during differentiation.

The paper develops a CRISPR-based mutagenesis approach combined with machine learning to model cis-regulatory features of ADAR-mediated RNA editing, explaining over 70% of editing level variation.

The paper identifies Zn72D as a regulator of ADAR-mediated RNA editing in Drosophila neurons and shows its conservation in mammals.

The paper identifies trans regulators of ADAR1 and ADAR2 using BioID and mass-spectrometry, validating novel interactors as RNA editing regulators.

The paper presents a spatial RNA editing map in the Drosophila brain, revealing distinct editing signatures across neuronal populations and identifying novel editing sites in conserved regions of essential neuronal genes.

The paper examines RNA editing changes in schizophrenia by analyzing postmortem brain samples and identifies genetic regulators and associations with schizophrenia GWAS loci.

This study identifies the THO nuclear export complex as critical for synaptic transcript export, synapse development, and neuronal survival in dopaminergic neurons across species.