Tao Sun

This paper develops inducible CRISPR/Cas9 systems with improved dynamic range and reduced off-target effects for precise gene perturbation.

The paper shows that ADAR1p150 prevents MDA5 and PKR activation through distinct mechanisms, preventing fatal autoinflammation.

The paper develops a CRISPR-based mutagenesis approach combined with machine learning to model cis-regulatory features of ADAR-mediated RNA editing, explaining over 70% of editing level variation.